Research

1. Kosugi Y, Kaku Y, Hinay AAJ, Guo Z, Uriu K, Kihara M, Saito F, Uwamino Y, Kuramochi J, Shirakawa K, Takaori-Kondo A, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Antiviral humoral immunity against SARS-CoV-2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals. Lancet Infect Dis. 24(3):e147-e148. https://doi.org/10.1016/S1473-3099(23)00784-3 (2024)

2. Ando Y, Tsukasaki M, Huynh NC, Zang S, Yan M, Muro R, Nakamura K, Komagamine M, Komatsu N, Okamoto K, Nakano K, Okamura T, Yamaguchi A, Ishihara K, Takayanagi H. The neutrophil-osteogenic cell axis promotes bone destruction in periodontitis. Int J Oral Sci. 16(1):18-8. https://doi.org/10.1038/s41368-023-00275-8 (2024)

3. Gu C, Fan S, Dahn R, Babujee L, Chiba S, Guan L, Maemura T, Pattinson D, Neumann G, Kawaoka Y. Characterization of a human H3N8 influenza virus. EBioMedicine. 101:105034. https://doi.org/10.1016/j.ebiom.2024.105034 (2024)

4. Nobe M, Maruzuru Y, Takeshima K, Koyanagi N, Kato A, Kawaguchi Y. MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1. Microbiol Immunol. https://doi.org/10.1111/1348-0421.13120 (2024)

5. Fan S, Kong H, Babujee L, Presler R,Jr, Jester P, Burke D, Pattinson D, Barr I, Smith D, Neumann G, Kawaoka Y. Assessment of the antigenic evolution of a clade 6B.1 human H1N1pdm influenza virus revealed differences between ferret and human convalescent sera. EBioMedicine. 101:105013. https://doi.org/10.1016/j.ebiom.2024.105013 (2024)

6. Tamura T, Mizuma K, Nasser H, Deguchi S, Padilla-Blanco M, Oda Y, Uriu K, Tolentino JEM, Tsujino S, Suzuki R, Kojima I, Nao N, Shimizu R, Wang L, Tsuda M, Jonathan M, Kosugi Y, Guo Z, Hinay AAJ, Putri O, Kim Y, Tanaka YL, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Saito A, Ito J, Irie T, Tanaka S, Zahradnik J, Ikeda T, Takayama K, Matsuno K, Fukuhara T, Sato K. Virological characteristics of the SARS-CoV-2 BA.2.86 variant. Cell Host Microbe. 32(2):170-180.e12. https://doi.org/10.1016/j.chom.2024.01.001 (2024)

7. Halfmann PJ, Loeffler K, Duffy A, Kuroda M, Yang JE, Wright ER, Kawaoka Y, Kane RS. Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine. Nat Commun. 15(1):1284-6. https://doi.org/10.1038/s41467-024-45495-6 (2024)

8. Tamura T, Irie T, Deguchi S, Yajima H, Tsuda M, Nasser H, Mizuma K, Plianchaisuk A, Suzuki S, Uriu K, Begum MM, Shimizu R, Jonathan M, Suzuki R, Kondo T, Ito H, Kamiyama A, Yoshimatsu K, Shofa M, Hashimoto R, Anraku Y, Kimura KT, Kita S, Sasaki J, Sasaki-Tabata K, Maenaka K, Nao N, Wang L, Oda Y, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ikeda T, Saito A, Matsuno K, Ito J, Tanaka S, Sato K, Hashiguchi T, Takayama K, Fukuhara T. Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant. Nat Commun. 15(1):1176-3. https://doi.org/10.1038/s41467-024-45274-3 (2024)

9. Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O. Structural basis for lysophosphatidylserine recognition by GPR34. Nat Commun. 15(1):902-z. https://doi.org/10.1038/s41467-024-45046-z (2024)

10. Kaku Y, Padilla-Blanco M, Kosugi Y, Uriu K, Hinay AAJ, Chen L, Plianchaisuk A, Kobiyama K, Ishii KJ, Genotype to Phenotype Japan (G2P-Japan) Consortium, Zahradnik J, Ito J, Sato K. Virological characteristics of the SARS-CoV-2 JN.1 variant. Lancet Infect Dis. 24(2):e82-7. Epub 2024 Jan 3. https://doi.org/10.1016/S1473-3099(23)00813-7 (2024)

11. Belongia EA, Petrie JG, Feldstein LR, Guan L, Halfmann PJ, King JP, Neumann G, Pattinson D, Rolfes MA, McLean HQ, Kawaoka Y. Neutralizing Immunity Against Antigenically Advanced Omicron BA.5 in Children After SARS-CoV-2 Infection. J Pediatric Infect Dis Soc. 13(1):100-104. https://doi.org/10.1093/jpids/piad109 (2024)

12. Yamayoshi S, Nagai E, Mitamura K, Hagihara M, Kobayashi R, Takahashi S, Shibata A, Uwamino Y, Hasegawa N, Iqbal A, Kamimaki I, Iwatsuki-Horimoto K, Nagamura-Inoue T, Kawaoka Y. Seroprevalence of severe acute respiratory syndrome coronavirus 2 N antibodies between December 2021 and march 2023 in Japan. Epidemiol Infect. 152:e24. https://doi.org/10.1017/S0950268824000141 (2024)

13. Oshima HS, Sano FK, Akasaka H, Iwama A, Shihoya W, Nureki O. Optimizing cryo-EM structural analysis of G(i)-coupling receptors via engineered G(t) and Nb35 application. Biochem Biophys Res Commun. 693:149361. https://doi.org/10.1016/j.bbrc.2023.149361 (2024)

14. Maruki T, Nomoto H, Iwamoto N, Yamamoto K, Kurokawa M, Iwatsuki-Horimoto K, Yamayoshi S, Suzuki Y, Kawaoka Y, Ohmagari N. Successful management of persistent COVID-19 using combination antiviral therapy (nirmatrelvir/ritonavir and remdesivir) and intravenous immunoglobulin transfusion in an immunocompromised host who had received CD20 depleting therapy for follicular lymphoma. J Infect Chemother. https://doi.org/10.1016/j.jiac.2024.01.008 (2024)

15. Kosugi Y, Plianchaisuk A, Putri O, Uriu K, Kaku Y, Hinay AAJ, Chen L, Kuramochi J, Sadamasu K, Yoshimura K, Asakura H, Nagashima M, Ito J, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Characteristics of the SARS-CoV-2 omicron HK.3 variant harbouring the FLip substitution. Lancet Microbe. https://doi.org/10.1016/S2666-5247(23)00373-7 (2024)

16. Whitworth IT, Knoener RA, Puray-Chavez M, Halfmann P, Romero S, Baddouh M, Scalf M, Kawaoka Y, Kutluay SB, Smith LM, Sherer NM. Defining Distinct RNA-Protein Interactomes of SARS-CoV-2 Genomic and Subgenomic RNAs. J Proteome Res. 23(1):149-160. https://doi.org/10.1021/acs.jproteome.3c00506 (2024)

17. Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK. Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors. Science. 383(6678):101-108. https://doi.org/10.1126/science.adj3347 (2024)

18. Ishizaka A, Koga M, Mizutani T, Yamayoshi S, Iwatsuki-Horimoto K, Adachi E, Suzuki Y, Kawaoka Y, Yotsuyanagi H. Association of gut microbiota with the pathogenesis of SARS-CoV-2 Infection in people living with HIV. BMC Microbiol. 24(1):6-5. https://doi.org/10.1186/s12866-023-03157-5 (2024)

19. Uraki R, Imai M, Ito M, Yamayoshi S, Kiso M, Jounai N, Miyaji K, Iwatsuki-Horimoto K, Takeshita F, Kawaoka Y. An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants. NPJ Vaccines. 9(1):4-0. https://doi.org/10.1038/s41541-023-00800-0 (2024)

20. Hagihara M, Hayashi H, Nakashima S, Imai Y, Nakano H, Uchida T, Inoue M, Sakai-Tagawa Y, Ito M, Yamayoshi S, Iwatsuki-Horimoto K, Suzuki Y, Kawaoka Y. Clinical Efficacy of Imdevimab/Casirivimab for Persistent Omicron SARS-CoV-2 Infection in Patients with Hematological Malignancies. Intern Med. https://doi.org/10.2169/internalmedicine.2900-23 (2024)

21. Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I. Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter. Nat Struct Mol Biol. 31(1):159-169. https://doi.org/10.1038/s41594-023-01134-0 (2024)

1. Uraki R, Kiso M, Iwatsuki-Horimoto K, Yamayoshi S, Ito M, Chiba S, Sakai-Tagawa Y, Imai M, Kashima Y, Koga M, Fuwa N, Okumura N, Hojo M, Iwamoto N, Kato H, Nakajima H, Ohmagari N, Yotsuyanagi H, Suzuki Y, Kawaoka Y. Characterization of a SARS-CoV-2 EG.5.1 clinical isolate in vitro and in vivo. Cell Rep. 42(12):113580. https://doi.org/10.1016/j.celrep.2023.113580 (2023)

2. Yamanouchi D, Kasuya G, Nakajo K, Kise Y, Nureki O. Dual allosteric modulation of voltage and calcium sensitivities of the Slo1-LRRC channel complex. Mol Cell. 83(24):4555-4569.e4. https://doi.org/10.1016/j.molcel.2023.11.005 (2023)

3. Safari C, Ghosh S, Andersson R, Johannesson J, Bath P, Uwangue O, Dahl P, Zoric D, Sandelin E, Vallejos A, Nango E, Tanaka R, Bosman R, Borjesson P, Dunevall E, Hammarin G, Ortolani G, Panman M, Tanaka T, Yamashita A, Arima T, Sugahara M, Suzuki M, Masuda T, Takeda H, Yamagiwa R, Oda K, Fukuda M, Tosha T, Naitow H, Owada S, Tono K, Nureki O, Iwata S, Neutze R, Branden G. Time-resolved serial crystallography to track the dynamics of carbon monoxide in the active site of cytochrome c oxidase. Sci Adv. 9(49):eadh4179. https://doi.org/10.1126/sciadv.adh4179 (2023)

4. Yamayoshi S, Ito M, Iwatsuki-Horimoto K, Yasuhara A, Okuda M, Hamabata T, Murakami J, Duong C, Yamamoto T, Kuroda Y, Maeda K, Kawaoka Y. Seroprevalence of SARS-CoV-2 antibodies in dogs and cats during the early and mid-pandemic periods in Japan. One Health. 17:100588. https://doi.org/10.1016/j.onehlt.2023.100588 (2023)

5. Hiramoto T, Inaba H, Baatartsogt N, Kashiwakura Y, Hayakawa M, Kamoshita N, Nishimasu H, Nureki O, Kinai E, Ohmori T. Genome editing of patient-derived iPSCs identifies a deep intronic variant causing aberrant splicing in hemophilia A. Blood Adv. 7(22):7017-7027. https://doi.org/10.1182/bloodadvances.2023010838 (2023)

6. Kingstad-Bakke B, Cleven T, Bussan H, Yount BL,Jr, Uraki R, Iwatsuki-Horimoto K, Koga M, Yamamoto S, Yotsuyanagi H, Park H, Mishra JS, Kumar S, Baric RS, Halfmann PJ, Kawaoka Y, Suresh M. Airway surveillance and lung viral control by memory T cells induced by COVID-19 mRNA vaccine. JCI Insight. 8(22):e172510. doi: 10.1172/jci.insight.172510. https://doi.org/10.1172/jci.insight.172510 (2023)

7. Iwatsuki-Horimoto K, Ito M, Okuda-Hamabata M, Takagi H, Imai M, Kawaoka Y. Cardiomyopathy Does Not Exacerbate the Severity of Pneumonia Caused by a SARS-CoV-2 Delta Variant in the J2N-k Hamster Model. Viruses. 15(12):2280. doi: 10.3390/v15122280. https://doi.org/10.3390/v15122280 (2023)

8. Kuroda M, Halfmann PJ, Thackray LB, Diamond MS, Feldmann H, Marzi A, Kawaoka Y. An Antiviral Role for TRIM14 in Ebola Virus Infection. J Infect Dis. 228:S514-S521. https://doi.org/10.1093/infdis/jiad325 (2023a)

9. Halfmann PJ, Borisevich V, Levine CB, Mire CE, Fenton KA, Geisbert TW, Kawaoka Y, Cross RW. The Mucin-Like Domain of the Ebola Glycoprotein Does Not Impact Virulence or Pathogenicity in Ferrets. J Infect Dis. 228:S587-S593. https://doi.org/10.1093/infdis/jiad240 (2023)

10. Kuroda M, Halfmann PJ, Kawaoka Y. Ebola Virus Infection Induces HCAR2 Expression Leading to Cell Death. J Infect Dis. 228:S508-S513. https://doi.org/10.1093/infdis/jiad344 (2023b)

11. Kobayashi D, Kai I, Faizah AN, Moi ML, Tajima S, Takasaki T, Sasaki T, Isawa H. Comparative analysis of the susceptibility of Aedes aegypti and Japanese Aedes albopictus to all dengue virus serotypes. Trop Med Health. 51(1):61-5. https://doi.org/10.1186/s41182-023-00553-5 (2023)

12. Maemura T, Guan L, Gu C, Eisfeld A, Biswas A, Halfmann P, Neumann G, Kawaoka Y. Characterization of highly pathogenic clade 2.3.4.4b H5N1 mink influenza viruses. EBioMedicine. 97:104827. https://doi.org/10.1016/j.ebiom.2023.104827 (2023)

13. Ota M, Nakano M, Nagafuchi Y, Kobayashi S, Hatano H, Yoshida R, Akutsu Y, Itamiya T, Ban N, Tsuchida Y, Shoda H, Yamamoto K, Ishigaki K, Okamura T, Fujio K. Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases. Ann Rheum Dis. 82(11):1455-1463. https://doi.org/10.1136/ard-2023-224421 (2023)

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22. Kikuchi C, Antonopoulos A, Wang S, Maemura T, Karamanska R, Lee C, Thompson AJ, Dell A, Kawaoka Y, Haslam SM, Paulson JC. Glyco-engineered MDCK cells display preferred receptors of H3N2 influenza absent in eggs used for vaccines. Nat Commun. 14(1):6178-0. https://doi.org/10.1038/s41467-023-41908-0 (2023)

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News Release　Study reveals the 3D structure of a protein involved in genome editing

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