Research

1. Koyanagi N, Hengphasatporn K, Kato A, Nobe M, Takeshima K, Maruzuru Y, Maenaka K, Shigeta Y, Kawaguchi Y. Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase. Proceedings of the National Academy of Sciences. 122(16):e2500264122. https://doi.org/10.1073/pnas.2500264122 (2025)

2. Yamada Y, Sankoda N, Yamada Y. In Vivo Reprogramming Highlights Epigenetic Regulation That Shapes Cancer Hallmarks. Cancer Sci. https://doi.org/10.1111/cas.70067 (2025)

3. Kobiyama K, Utsumi D, Kaku Y, Sasaki E, Yasui F, Okamura T, Onodera T, Tobuse AJ, Sakkour A, Amiry AF, Hayashi T, Temizoz B, Liu K, Negishi H, Toyama-Sorimachi N, Kohara M, Sawasaki T, Takagi J, Sato K, Takahashi Y, Yasutomi Y, Ishii KJ. Immunological analysis of LC16m8 vaccine: preclinical and early clinical insights into mpox. eBioMedicine. 115:105703. https://doi.org/10.1016/j.ebiom.2025.105703 (2025)

4. Yamamoto K, Nagatoishi S, Matsunaga R, Nakakido M, Kuroda D, Tsumoto K. Affinity-stability trade-off mechanism of residue 35 in framework region 2 of VHH antibodies with β-hairpin CDR3. Protein Sci. 34(4):e70095. https://doi.org/10.1002/pro.70095 (2025)

5. Iwatsuki-Horimoto K, Uraki R, Ito M, Wang T, Guan L, Halfmann P, Eisfeld A, Neumann G, Yamayoshi S, Kawaoka Y. Transmission of bovine H5N1 virus in a hamster model. J Virol. https://doi.org/10.1128/jvi.00147-25 (2025)

6. Koide S, Oshima M, Kamiya T, Zheng Z, Liu Z, Rizq O, Nishiyama A, Murakami K, Yamada Y, Nakajima-Takagi Y, Rahmutulla B, Kaneda A, Yokoyama K, Yusa N, Imoto S, Miura F, Ito T, Tamura T, Nerlov C, Yamashita M, Iwama A. Tracking clusterin expression in hematopoietic stem cells reveals their heterogeneous composition across the lifespan. Blood. https://doi.org/10.1182/blood.2024025776 (2025)

7. Weller C, Bartok O, McGinnis CS, Palashati H, Chang T, Malko D, Shmueli MD, Nagao A, Hayoun D, Murayama A, Sakaguchi Y, Poulis P, Khatib A, Erlanger Avigdor B, Gordon S, Cohen Shvefel S, Zemanek MJ, Nielsen MM, Boura-Halfon S, Sagie S, Gumpert N, Yang W, Alexeev D, Kyriakidou P, Yao W, Zerbib M, Greenberg P, Benedek G, Litchfield K, Petrovich-Kopitman E, Nagler A, Oren R, Ben-Dor S, Levin Y, Pilpel Y, Rodnina M, Cox J, Merbl Y, Satpathy AT, Carmi Y, Erhard F, Suzuki T, Buskirk AR, Olweus J, Ruppin E, Schlosser A, Samuels Y. Translation dysregulation in cancer as a source for targetable antigens. Cancer cell. https://doi.org/10.1016/j.ccell.2025.03.003 (2025) 

8. Izuka S, Komai T, Tsuchida Y, Tsuchiya H, Okamura T, Fujio K. The role of monocytes and macrophages in idiopathic inflammatory myopathies: insights into pathogenesis and potential targets. Frontiers in Immunology. 16:1567833. https://doi.org/10.3389/fimmu.2025.1567833 (2025)

9. Furusawa Y, Kiso M, Uraki R, Sakai-Tagawa Y, Nagai H, Koga M, Kashima Y, Hojo M, Iwamoto N, Iwatsuki-Horimoto K, Ohmagari N, Suzuki Y, Yotsuyanagi H, Halfmann PJ, Kamitani W, Yamayoshi S, Kawaoka Y. Amino acid substitutions in NSP6 and NSP13 of SARS-CoV-2 contribute to superior virus growth at low temperatures. J Virol. 99(3):e0221724–24. Epub 2025 Feb 12. https://doi.org/10.1128/jvi.02217-24 (2025)

10. Park H, Kingstad-Bakke B, Cleven T, Jung M, Kawaoka Y, Suresh M. Diversifying T-cell responses: safeguarding against pandemic influenza with mosaic nucleoprotein. J Virol. 99(3):e0086724–24. Epub 2025 Feb 3. https://doi.org/10.1128/jvi.00867-24 (2025)

11. Ukaji T, Arai D, Tsutsumi H, Nakagawa R, Matsumoto F, Ikeda K, Nureki O, Kamiya K. AAV-mediated base editing restores cochlear gap junction in GJB2 dominant-negative mutation-associated syndromic hearing loss model. JCI Insight. 10(5):e185193. doi: 10.1172/jci.insight.185193. https://doi.org/10.1172/jci.insight.185193 (2025)

12. Sato N, Nakano Y, Matsuki Y, Tomomatsu S, Li S, Matsuo Y, Inada T. Crucial roles of Grr1 in splicing and translation of HAC1 mRNA upon unfolded stress response. Nat Commun. 16(1):2172–1. https://doi.org/10.1038/s41467-025-57360-1 (2025)

13. Matsunaga R, Tsumoto K. FASTIA: A rapid and accessible platform for protein variant interaction analysis demonstrated with a single-domain antibody. Protein Sci. 34(3):e70065. https://doi.org/10.1002/pro.70065 (2025)

14. Takashita E, Shimizu K, Kawakami C, Momoki T, Saikusa M, Ozawa H, Kumazaki M, Usuku S, Tanaka N, Senda R, Okubo I, Fujisaki S, Nagata S, Morita H, Miura H, Watanabe K, Nakauchi M, Matsuzaki Y, Watanabe S, Hasegawa H, Kawaoka Y. Impact of COVID-19 on Respiratory Virus Infections in Children, Japan, 2018-2023. Immun Inflamm Dis. 13(3):e70176. https://doi.org/10.1002/iid3.70176 (2025)

15. Yano S, Asami N, Kishi Y, Takeda I, Kubotani H, Hattori Y, Kitazawa A, Hayashi K, Kubo K, Saeki M, Maeda C, Hiraki C, Teruya R, Taketomi T, Akiyama K, Okajima-Takahashi T, Sato B, Wake H, Gotoh Y, Nakajima K, Ichinohe T, Nagata T, Chiba T, Tsuruta F. Propagation of neuronal micronuclei regulates microglial characteristics. Nat Neurosci. 28(3):487–498. https://doi.org/10.1038/s41593-024-01863-5 (2025) 

16. Nakatsukasa Y, Yamada Y, Yamada Y. Research of in vivo reprogramming toward clinical applications in regenerative medicine: A concise review. Regenerative therapy. 28:12–19. https://doi.org/10.1016/j.reth.2024.11.008 (2025) 

17. Kobayashi M, Kobayashi N, Deguchi K, Omori S, Ichinohe T. SARS-CoV-2 infection primes cross-protective respiratory IgA in a MyD88- and MAVS-dependent manner. NPJ Vaccines. 10(1):40–z. https://doi.org/10.1038/s41541-025-01095-z (2025)

18. Oka E, Ueda Y, Yagi A, Machida M, Furuse Y, Tabuchi T. Challenges to promoting maternal respiratory syncytial virus vaccination in Japan. Vaccine. 48:126767. https://doi.org/10.1016/j.vaccine.2025.126767 (2025)

19. Lytras S, Lamb KD, Ito J, Grove J, Yuan K, Sato K, Hughes J, Robertson DL. Pathogen genomic surveillance and the AI revolution. J Virol. 99(2):e0160124–24. Epub 2025 Jan 29. https://doi.org/10.1128/jvi.01601-24 (2025)

20. Ise W, Koike T, Shimada N, Yamamoto H, Tai Y, Shirai T, Kawakami R, Kuwabara M, Kawai C, Shida K, Inoue T, Hojo N, Ichiyama K, Sakaguchi S, Shiroguchi K, Suzuki K, Kurosaki T. KLF2 expression in IgG plasma cells at their induction site regulates the migration program. J Exp Med. 222(5):e20241019. https://doi.org/10.1084/jem.20241019 (2025)

21. Suzuki T, Ogizawa A, Ishiguro K, Nagao A. Biogenesis and roles of tRNA queuosine modification and its glycosylated derivatives in human health and diseases. Cell chemical biology. 32(2):227–238. https://doi.org/10.1016/j.chembiol.2024.11.004 (2025)  

22. Yu X, Ni Z, Wang Y, Wang J, Deng G, Shi J, Kong H, Jiang Y, Tian G, Li C, Kawaoka Y, Chen H, Wang J. Claudin-11 plays a pivotal role in the clathrin-mediated endocytosis of influenza A virus. Sci China Life Sci. https://doi.org/10.1007/s11427-024-2856-y (2025)

23. Furuse Y, Komorizono R, Fujita N. Need to revisit culture isolation for detecting viraemia. Lancet Microbe. :101080. https://doi.org/10.1016/j.lanmic.2025.101080 (2025)

24. Hastie KM, Salie ZL, Ke Z, Halfmann PJ, DeWald LE, McArdle S, Grinyo A, Davidson E, Schendel SL, Hariharan C, Norris MJ, Yu X, Chennareddy C, Xiong X, Heinrich M, Holbrook MR, Doranz B, Crozier I, Kawaoka Y, Branco LM, Kuhn JH, Briggs JAG, Worwa G, Davis CW, Ahmed R, Saphire EO. Anti-Ebola virus mAb 3A6 protects highly viremic animals from fatal outcome via binding GP((1,2)) in a position elevated from the virion membrane. Nat Commun. 16(1):1293–2. https://doi.org/10.1038/s41467-025-56452-2 (2025)

25. Uraki R, Ito M, Kiso M, Iwatsuki-Horimoto K, Endo M, Yamayoshi S, Kawaoka Y. An XBB.1.5-based inactivated SARS-CoV-2 vaccine partially protects against XBB.1.5 and JN.1 strains in hamsters. npj Viruses. 3(1):7. https://doi.org/10.1038/s44298-025-00096-y (2025) 

26. Uriu K, Kaku Y, Uwamino Y, Fujiwara H, Saito F, Genotype to Phenotype Japan (G2P-Japan) Consortium, Sato K. Antiviral humoral immunity induced by JN.1 monovalent mRNA vaccines against SARS-CoV-2 omicron subvariants including JN.1, KP.3.1.1, and XEC. Lancet Infect Dis. 25(2):e61–7. Epub 2024 Dec 10. https://doi.org/10.1016/S1473-3099(24)00810-7 (2025)

27. Ujiie K, Nakakido M, Kinoshita S, Caaveiro JMM, Entzminger CK, Okumura SCJ, Maruyama T, Miyauchi K, Matano T, Tsumoto K. Specific recognition mechanism of an antibody to sulfated tyrosine and its potential use in biological research. J Biol Chem. 301(2):108176. https://doi.org/10.1016/j.jbc.2025.108176 (2025)

28. Kakizaki M, Hashimoto R, Nagata N, Yamamoto T, Okura T, Katoh H, Kitai Y, Akahori Y, Shirato K, Ryo A, Takayama K, Takeda M. The respective roles of TMPRSS2 and cathepsins for SARS-CoV-2 infection in human respiratory organoids. J Virol. 99(1):e0185324–24. Epub 2024 Nov 27. https://doi.org/10.1128/jvi.01853-24 (2025)

29. Kanno A, Tanifuji R*, Yoshida S, Sato S, Maki-Yonekura S, Takaba K, Kang J, Tono K, Yonekura K, Oguri H. Streamlined modular synthesis of saframycin substructure via copper-catalyzed three-component assembly and gold-promoted 6-endo cyclization. Beilstein Journal of Organic Chemistry. 21:226–233. https://doi.org/10.3762/bjoc.21.14 (2025)

30. Saegusa K, Tsuchida Y, Komai T, Tsuchiya H, Fujio K. Advances in Targeted Therapy for Systemic Lupus Erythematosus: Current Treatments and Novel Approaches. Int J Mol Sci. 26(3):929. doi: 10.3390/ijms26030929. https://doi.org/10.3390/ijms26030929 (2025)

31. Sekine R, Takeda K, Suenaga T, Tsuno S, Kaiya T, Kiso M, Yamayoshi S, Takaku Y, Ohno S, Yamaguchi Y, Nishizawa S, Sumitomo K, Ikuta K, Kanda T, Kawaoka Y, Nishimura H, Kuge S. G-quadruplex-forming small RNA inhibits coronavirus and influenza A virus replication. Communications Biology. 8(1):27. https://doi.org/10.1038/s42003-024-07351-7 (2025)

32. Imai M, Ueki H, Ito M, Iwatsuki-Horimoto K, Kiso M, Biswas A, Trifkovic S, Cook N, Halfmann PJ, Neumann G, Eisfeld AJ, Kawaoka Y. Highly pathogenic avian H5N1 influenza A virus replication in ex vivo cultures of bovine mammary gland and teat tissues. Emerging Microbes & Infections. 14(1):2450029. https://doi.org/10.1080/22221751.2025.2450029 (2025)

33. Taguchi J, Yamada Y, Ohta S, Nakasuka F, Yamamoto T, Ozawa M, Yamada Y. A versatile in vivo platform for reversible control of transgene expression in adult tissues. Stem cell reports. 20(1):102373. https://doi.org/10.1016/j.stemcr.2024.11.003 (2025) 

34. Yang J, Song I, Saito M, Hartanto T, Ichinohe T, Fukuda S. Partially hydrolyzed guar gum attenuates symptoms and modulates the gut microbiota in a model of SARS-CoV-2 infection. Gut microbiome (Cambridge, England). 6:e1. https://doi.org/10.1017/gmb.2024.7 (2025)  

35. Ueki H, Wang I, Kiso M, Horie K, Iida S, Mine S, Ujie M, Hsu H, Wu CH, Imai M, Suzuki T, Kamitani W, Kawakami E, Kawaoka Y. Neutrophil adhesion to vessel walls impairs pulmonary circulation in COVID-19 pathology. Nat Commun. 16(1):455–0. https://doi.org/10.1038/s41467-024-55272-0 (2025)

36. Ishizaka A, Tamura A, Koga M, Mizutani T, Yamayoshi S, Iwatsuki-Horimoto K, Yasuhara A, Yamamoto S, Nagai H, Adachi E, Suzuki Y, Kawaoka Y, Yotsuyanagi H. Dysbiosis of gut microbiota in COVID-19 is associated with intestinal DNA phage dynamics of lysogenic and lytic infection. Microbiology Spectrum. 13(1) https://doi.org/10.1128/spectrum.00998-24 (2025)

37. Halfmann PJ, Patel RS, Loeffler K, Yasuhara A, van de Velde L, Yang JE, Chervin J, Troxell C, Huang M, Zheng N, Wright ER, Thomas PG, Wilson PC, Kawaoka Y, Kane RS. Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice. Nature Communications. 16(1):462. https://doi.org/10.1038/s41467-025-55824-y (2025)

38. Higashi-Kuwata N, Bulut H, Hayashi H, Tsuji K, Ogata-Aoki H, Kiso M, Takamune N, Kishimoto N, Hattori S, Ishii T, Kobayakawa T, Nakano K, Shimizu Y, Das D, Saruwatari J, Hasegawa K, Murayama K, Sukenaga Y, Takamatsu Y, Yoshimura K, Aoki M, Furusawa Y, Okamura T, Yamayoshi S, Kawaoka Y, Misumi S, Tamamura H, Mitsuya H. An orally available P1'-5-fluorinated M(pro) inhibitor blocks SARS-CoV-2 replication without booster and exhibits high genetic barrier. PNAS Nexus. 4(1):pgae578. https://doi.org/10.1093/pnasnexus/pgae578 (2025)

39. Gu C, Babujee L, Pattinson D, Chiba S, Jester P, Maemura T, Neumann G, Kawaoka Y. Development of broadly protective influenza B vaccines. NPJ Vaccines. 10(1):2–w. https://doi.org/10.1038/s41541-024-01058-w (2025)

40. Tsutsui M, Tsunekawa Y, Wada M, Arima A, Onodera A, Nishina M, Nagoya M, Baba Y, Kawai T, Okada T. Enhanced Discriminability of Viral Vectors in Viscous Nanopores. Small methods. :e2401321. https://doi.org/10.1002/smtd.202401321 (2025) 

41. Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu M, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee H, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Thoughts for the future. Nat Chem Biol. 21(1):6–15. https://doi.org/10.1038/s41589-024-01802-2 (2025) 

42. Noji H, Minagawa Y, Ueno H. Digital bioassay. Oyo Buturi. 94(1):3–9. https://doi.org/10.11470/oubutsu.94.1_3 (2025)

1. Nagamura R, Kujirai T, Kato J, Shuto Y, Kusakizako T, Hirano H, Endo M, Toki S, Saika H, Kurumizaka H, Nureki O. Structural insights into how Cas9 targets nucleosomes. Nat Commun. 15(1):10744–z. https://doi.org/10.1038/s41467-024-54768-z (2024)

2. Amano R, Takahashi M, Haga K, Yamamoto M, Goto K, Ichinose A, Hamada M, Gohda J, Inoue J, Kawaguchi Y, Moi ML, Nakamura Y. A chimeric RNA consisting of siRNA and aptamer for inhibiting dengue virus replication. NAR Mol Med. 1(4):ugae025. https://doi.org/10.1093/narmme/ugae025 (2024) 

3. Katoh H, Kimura R, Sekizuka T, Matsuoka K, Hosogi M, Kitai Y, Akahori Y, Kato F, Kataoka M, Kobayashi H, Nagata N, Suzuki T, Ohkawa Y, Oki S, Takeda M. Structural and molecular properties of mumps virus inclusion bodies. Science Advances. 10(49):eadr0359. https://doi.org/10.1126/sciadv.adr0359 (2024)

4. Kim KQ, Li JJ, Nanjaraj Urs AN, Pacheco ME, Lasehinde V, Denk T, Tesina P, Tomomatsu S, Matsuo Y, McDonald E, Beckmann R, Inada T, Green R, Zaher HS. Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes. Mol Cell. 84(23):4594–4611.e9. https://doi.org/10.1016/j.molcel.2024.10.029 (2024)

5. Ay S, Burlaud-Gaillard J, Gazi A, Tatirovsky Y, Cuche C, Diana J, Scoca V, Di Santo JP, Roingeard P, Mammano F, Di Nunzio F. In vivo HIV-1 nuclear condensates safeguard against cGAS and license reverse transcription. EMBO J. 44(1):166–199. https://doi.org/10.1038/s44318-024-00316-w (2025)

6. Iijima N, Yamaguchi M, Hayashi T, Rui Y, Ohira Y, Miyamoto Y, Niino M, Okuno T, Suzuki O, Oka M, Ishii KJ. miR-147-3p in pathogenic CD4 T cells controls chemokine receptor expression for the development of experimental autoimmune diseases. J Autoimmun. 149:103319. https://doi.org/10.1016/j.jaut.2024.103319 (2024)

7. Kaku Y, Okumura KAU-K, Kawakubo S, Uriu K, Chen L, Kosugi Y, Uwamino Y, Begum MM, Leong S, Ikeda T, Sadamasu K, Asakura H, Nagashima M, Yoshimura K, Genotype to Phenotype Japan (G2P-Japan) Consortium, Ito J, Sato K. Virological characteristics of the SARS-CoV-2 XEC variant. Lancet Infect Dis. 24(12):e736–X. Epub 2024 Nov 6. https://doi.org/10.1016/S1473-3099(24)00731-X (2024)

8. Togashi T, Baatartsogt N, Nagao Y, Kashiwakura Y, Hayakawa M, Hiramoto T, Fujiwara T, Morishita E, Nureki O, Ohmori T. Cure of Congenital Purpura Fulminans via Expression of Engineered Protein C Through Neonatal Genome Editing in Mice. Arterioscler Thromb Vasc Biol. 44(12):2616–2627. https://doi.org/10.1161/ATVBAHA.123.319460 (2024)

9. Kobayashi M, Kobayashi N, Deguchi K, Omori S, Nagai M, Fukui R, Song I, Fukuda S, Miyake K, Ichinohe T. TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages. Plos Pathogens. 20(12):e1012776. https://doi.org/10.1371/journal.ppat.1012776 (2024)

10. Zhou NE, Tang S, Bian X, Parai MK, Krieger IV, Flores A, Jaiswal PK, Bam R, Wood JL, Shi Z, Stevens LJ, Scobey T, Diefenbacher MV, Moreira FR, Baric TJ, Acharya A, Shin J, Rathi MM, Wolff KC, Riva L, Bakowski MA, Mcnamara CW, Catanzaro NJ, Graham RL, Schultz DC, Cherry S, Kawaoka Y, Halfmann PJ, Baric RS, Denison MR, Sheahan TP, Sacchettini JC. An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo. Cell Reports. 43(11):114929. https://doi.org/10.1016/j.celrep.2024.114929 (2024)

11. Anzurez A, Runtuwene L, Dang TTT, Nakayama-Hosoya K, Koga M, Yoshimura Y, Sasaki H, Miyata N, Miyazaki K, Takahashi Y, Suzuki T, Yotsuyanagi H, Tachikawa N, Matano T, Kawana-Tachikawa A. Characterization of the Proinflammatory Cytokine Profile during Acute SARS-CoV-2 Infection in People with Human Immunodeficiency Virus. Jpn J Infect Dis. 77(6):301–310. https://doi.org/10.7883/yoken.JJID.2024.184 (2024)

12. Iwatsuki-Horimoto K, Kiso M, Ito M, Yamayoshi S, Kawaoka Y. Sensitivity of rodents to SARS-CoV-2: Gerbils are susceptible to SARS-CoV-2, but guinea pigs are not. npj Viruses. 2(1):59. https://doi.org/10.1038/s44298-024-00068-8 (2024) 

13. Kurata T, Takegawa M, Ohira T, Syroegin EA, Atkinson GC, Johansson MJO, Polikanov YS, Garcia-Pino A, Suzuki T, Hauryliuk V. Toxic small alarmone synthetase FaRel2 inhibits translation by pyrophosphorylating tRNA Gly and tRNA Thr. Science advances. 10(46):eadr9624. https://doi.org/10.1126/sciadv.adr9624 (2024) 

14. Ota A, Iguchi T, Nitta S, Muro R, Mino N, Tsukasaki M, Penninger JM, Nitta T, Takayanagi H. Synchronized development of thymic eosinophils and thymocytes. Int Immunol. 36(12):617–628. https://doi.org/10.1093/intimm/dxae037 (2024)

15. Tanaka R, Tamao K, Ono M, Yamayoshi S, Kawaoka Y, Su'etsugu M, Noji H, Tabata KV. In vitro one-pot construction of influenza viral genomes for virus particle synthesis based on reverse genetics system. PLoS One. 19(11):e0312776. https://doi.org/10.1371/journal.pone.0312776 (2024)

16. Akichika S, Suzuki T. Cap-specific m6Am modification: A transcriptional anti-terminator by sequestering PCF11 with implications for neuroblastoma therapy. Molecular cell. 84(21):4051–4052. https://doi.org/10.1016/j.molcel.2024.10.014 (2024) 

17. Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei F, Shihoya W, Nureki O. Structural insights into the agonist selectivity of the adenosine A3 receptor. Nature Communications. 15(1):9294. https://doi.org/10.1038/s41467-024-53473-1 (2024)

18. Akasaka H, Sano FK, Shihoya W, Nureki O. Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists. Commun Biol. 7(1):1444–y. https://doi.org/10.1038/s42003-024-07152-y (2024)

19. Chiba S, Kiso M, Yamada S, Someya K, Onodera Y, Yamaguchi A, Matsunaga S, Jounai N, Yamayoshi S, Takeshita F, Kawaoka Y. Protective effects of an mRNA vaccine candidate encoding H5HA clade 2.3.4.4b against the newly emerged dairy cattle H5N1 virus. eBioMedicine. 109:105408. https://doi.org/10.1016/j.ebiom.2024.105408 (2024) 

20. Muro R, Nitta T, Nitta S, Tsukasaki M, Asano T, Nakano K, Okamura T, Nakashima T, Okamoto K, Takayanagi H. Transcript splicing optimizes the thymic self-antigen repertoire to suppress autoimmunity. J Clin Invest. 134(20):e179612. https://doi.org/10.1172/JCI179612 (2024)

21. Yajima H, Anraku Y, Kaku Y, Kimura KT, Plianchaisuk A, Okumura K, Nakada-Nakura Y, Atarashi Y, Hemmi T, Kuroda D, Takahashi Y, Kita S, Sasaki J, Sumita H, Ito J, Maenaka K, Sato K, Hashiguchi T. Structural basis for receptor-binding domain mobility of the spike in SARS-CoV-2 BA.2.86 and JN.1. Nature Communications. 15(1):8574. https://doi.org/10.1038/s41467-024-52808-2 (2024)

22. Gao P, Morita N, Shinkura R. Role of mucosal IgA antibodies as novel therapies to enhance mucosal barriers. Semin Immunopathol. 47(1):1–4. https://doi.org/10.1007/s00281-024-01027-4 (2024)

23. Shimoyama M, Nakada-Tsukui K, Nozaki T. EhRacM differentially regulates macropinocytosis and motility in the enteric protozoan parasite Entamoeba histolytica. PLoS Pathog. 20(11):e1012364. https://doi.org/10.1371/journal.ppat.1012364 (2024)

24. Kawataki S, Kubota Y, Katayama K, Imoto S, Takekawa M. GADD45beta-MTK1 signaling axis mediates oncogenic stress-induced activation of the p38 and JNK pathways. Cancer Sci. https://doi.org/10.1111/cas.16389 (2024)

25. Umegaki T, Moriizumi H, Ogushi F, Takekawa M, Suzuki T. Molecular dynamics simulations of a multicellular model with cell-cell interactions and Hippo signaling pathway. PLoS computational biology. 20(11):e1012536. https://doi.org/10.1371/journal.pcbi.1012536 (2024)  

26. Kuwata T, Kaku Y, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Uraki R, Okazaki K, Minami R, Nagasaki Y, Nagashima M, Yoshida I, Sadamasu K, Yoshimura K, Ito M, Kiso M, Yamayoshi S, Imai M, Ikeda T, Sato K, Toyoda M, Ueno T, Inoue T, Tanaka Y, Kimura KT, Hashiguchi T, Sugita Y, Noda T, Morioka H, Kawaoka Y, Matsushita S, Genotype to Phenotype Japan (G2P-Japan) Consortium. Induction of IGHV3-53 public antibodies with broadly neutralising activity against SARS-CoV-2 including Omicron subvariants in a Delta breakthrough infection case. EBioMedicine. 110:105439. https://doi.org/10.1016/j.ebiom.2024.105439 (2024)

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News Release　Study reveals the 3D structure of a protein involved in genome editing

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